December 20th, 2013 | Category: Mathematics, Metabolic engineering, Papers | Leave a comment

Multi-enzyme pathway engineering

Engineering metabolic pathways, whether for pharmaceuticals or fuels, involves many trade-offs. Flux imbalances (for example where flux through the first step exceeds flux through the second) can lead to the accumulation of toxic intermediates. Moreover, expressing heterologous proteins beyond that which is necessary can place a burden upon the cell for protein, rather than product, […]

March 28th, 2013 | Category: Papers, Protein design, Synthetic Biology | Leave a comment

Cas9 – a new genome editing tool

Cas9 – could it change Biotech forever? Well, you’ll have to follow that link to find out. In the meantime, here’s a very brief introduction. CRISPR – clustered, regularly interspersed, short palindromic repeats – are used by bacteria and archaea to provide protection against foreign nucleic acid sequences.

February 13th, 2013 | Category: Beginner's Guides, Computing, Information processing, Papers, Synthetic Biology | Leave a comment

Turning cells into computers

Any would-be Exeter iGEMers may be interested in this article, appearing in Nature, about the current state of play in biocomputing: i.e. using biological molecules to perform computation. The article introduces the work presented in the paper, “Synthetic circuits integrating logic and memory in living cells”

August 16th, 2012 | Category: Beginner's Guides, Papers, Synthetic Biology | Leave a comment

6 years and counting: PLOS Collections

PLOS One has launched the Synthetic Biology Collection, a collection of over 50 papers published in the last six years (all open access, of course): This collection aims to highlight PLOS ONE’s role in the emerging interdisciplinary field of synthetic biology. The collection has its roots in PLOS ONE’s very first issue, which included two publications […]

June 22nd, 2012 | Category: Arabidopsis, iGEM, Metabolic engineering, Papers | Leave a comment

Harvard iGEM 2010

The iGEM team from Harvard 2010, and their iGarden have found their way to publication in the Journal of Biological Engineering. Their new paper, “A BioBrick compatible strategy for genetic modification of plants“

May 23rd, 2012 | Category: Computing, Information processing, Media coverage, Papers, Synthetic Biology | Leave a comment

Data storage in living cells

There’s a lot of interest (including at the Beeb) in a new paper from Drew Endy published in PNAS: rewritable digital data storage in live cells via engineered control of recombination directionality.

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