December 20th, 2013 | Category: Mathematics, Metabolic engineering, Papers | Leave a comment

Multi-enzyme pathway engineering

Engineering metabolic pathways, whether for pharmaceuticals or fuels, involves many trade-offs. Flux imbalances (for example where flux through the first step exceeds flux through the second) can lead to the accumulation of toxic intermediates. Moreover, expressing heterologous proteins beyond that which is necessary can place a burden upon the cell for protein, rather than product, […]

November 29th, 2013 | Category: Metabolic engineering, Protein design, Synthetic Biology | Leave a comment

Potential PhD Position: Biosynthetic Lego: Building antibiotic assembly lines from first principles

There is a PhD position available with Paul Race at Bristol that I will be co-supervising (subject to securing the funding). If successful this will be funded through the South West Doctoral Training Partnership. The PhD will be a fully-funded, four-year programme designed to provide training in cutting edge world-class bioscience and food security research skills. […]

November 28th, 2013 | Category: Beginner's Guides, E. coli, iGEM, Microbiology, Saccharomyces, Synthetic Biology | Leave a comment

Synthetic Biology & its Application

As promised here are a few notes and links on the key points of today’s lecture: Synthetic Biology and its Application (28th November 2013). Follow the links for further information. Synthetic Biology – it’s not what you do, it’s the way that you do it. Three key aims of synthetic biology were highlighted: the first […]

October 25th, 2013 | Category: E. coli, Media coverage, Metabolic engineering, Video | Leave a comment

German Diesel and Other News

For German coverage of our biofuels paper, look no further than 3sat. The article starts at 22mins and features interviews and cameos from many in the mezz. lab. Keep your eyes pealed for a stealth technician around the 23.40min mark. Further good news is a nomination for a University of Exeter Impact Awards in the ‘Outstanding impact […]

March 28th, 2013 | Category: Papers, Protein design, Synthetic Biology | Leave a comment

Cas9 – a new genome editing tool

Cas9 – could it change Biotech forever? Well, you’ll have to follow that link to find out. In the meantime, here’s a very brief introduction. CRISPR – clustered, regularly interspersed, short palindromic repeats – are used by bacteria and archaea to provide protection against foreign nucleic acid sequences.

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