March 28th, 2013 | Category: Papers, Protein design, Synthetic Biology | Leave a comment

Cas9 – a new genome editing tool

Cas9 – could it change Biotech forever? Well, you’ll have to follow that link to find out. In the meantime, here’s a very brief introduction. CRISPR – clustered, regularly interspersed, short palindromic repeats – are used by bacteria and archaea to provide protection against foreign nucleic acid sequences.

September 27th, 2012 | Category: iGEM | Leave a comment

The European iGEM wiki-freeze is upon us

Well the iGEM wiki-freeze is upon us and Team:Exeter managed to put the final touches to their wiki with 9 minutes to spare. Please follow the link (here) or click on the logo below to find out more about their project.

April 27th, 2012 | Category: Metabolic engineering, Papers, Synthetic Biology | Leave a comment

SynBio Smörgåsbord

There have been a number of interesting stories recently that I have been meaning to write about, but time has got the better of me. There is a growing list of ‘draft’ posts at The 4th Domain, so I thought I would roll them all into one post

April 17th, 2012 | Category: Papers, Synthetic Biology | Leave a comment

Genetic switchboard for synthetic biology applications

A very short post to say that there is a new paper in PNAS that some might find interesting: Genetic switchboard for synthetic biology applications.

April 12th, 2012 | Category: Papers, Synthetic Biology | 2 comments

Expressing bacterial operons in plants

One of the advantages of working with bacteria is that genes can be clustered together under control of a single promoter (known as an operon). Multiple protein products can therefore be generated from a single messenger RNA strand (the mRNA is said to be polycistronic (Fig. 1)).

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